GE Healthcare recently developed a novel method (illustraTM triplePrep Kit) to isolate high quality genomic DNA (gDNA), total RNA and total denatured proteins from a single undivided sample in less than one hour. It allows researchers to correlate DNA, RNA and protein data directly from exact same sample and to generate more data from as little as 1 mg tissue. The performance of triplePrep was tested with a wide range of animal tissues and cultured cells in various downstream applications. When compared with commonly used sample preparation methods, triplePrep not only generates higher yields of high quality DNA, RNA and proteins from small samples but also provides a faster and more flexible workflow.