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VIIISelect- Highly selective to recombinant b-domain depleted Factor VIII
- Efficient purification of recombinant b-domain depleted Factor VIII with high yields and retained activity
- Excellent scalability
- Non-animal derived
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VIIISelect
Technical Information
VIIISelect is an affinity medium designed for the purification of recombinant b-domain depleted factor VIII, a key recombinant blood factor used for treatment of Hemophilia A. Due to the sensitive nature of the factor VIII molecule it is important to limit the number of steps in the downstream process. The high selectivity and yields obtained using VIIISelect enable a robust and efficient purification process with excellent purity obtained in one step.
| TECHNICAL SPECIFICATIONS |
| Composition | Highly crosslinked agarose |
| Particle size | 75 µm average (d50, vol) |
| Ligand | 13 kD recombinant protein produced in S. cerevisiae. Binds to b-domain depleted factor VIII molecules. |
| Coupling chemistry | NHS |
| Pressure/flow spec | At least 300 cm/hour in a BPG 300 column with 20 cm bed height at less than 2 bars |
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Product related documents
Data file
BioProcess media. Process-scale quantities are available.