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Protein Purification
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Antibody purification
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Filtration
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Filtration


Sample concentration at research scale is often required during purification to reduce the sample volume before applying the sample to a gel filtration column. Vivaspin™ sample concentrators are disposable devices designed to concentrate biological samples by membrane ultrafiltration.

Vivaspin

  • One-step sample concentration in a single tube for minimal sample handling and reduced sample loss.
  • Patented dead-stop technology, which ensures that samples cannot be concentrated to dryness and enables direct concentrate recovery.
  • Vertical polyethersulfone membrane minimizes membrane blockage and tolerates high flow rates.

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The purification of biological therapeutics generally involves the use of cross flow filtration (tangential flow filtration) or normal flow filtration (dead ended filtration), combined with chromatographic separations. Cross flow filtration and normal flow filtration retain matter through size exclusion and are complementary to chromatography’s selectivity.
GE Healthcare provides several classes of filtration products. If you are not sure what class of product you need, please use our FilterBrain - Product Selection Tool. The product selection below features an array of membrane products and media that, together with GE Healthcare's systems, provide optimal membrane selection, ease of validation, and reliable, scalable platforms from the laboratory to production volumes.



Filtration systems

Cross flow filtration systems

  • The UNICORN™ control system allows our automated systems to translate directly from laboratory to process and communicate seamlessly with chromatography skids
  • The filtration system family is capable of processing batches of less then 200 ml to more then 10,000 l of feed material
  • Most of the systems are capable of operating both hollow fiber cartridges and cassettes

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Ultrafiltration - cassettes

Ultrafiltration cassettes

  • Sharp selectivity which translates to enhanced yield concentration of proteins
  • Designed specifically for reliable linear scale up
  • The flat sheet devices offer lot to lot consistency, quality, and plug and play operation
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Ultrafiltration - hollow fibers

Ultrafiltration hollow fiber cartridges


For:
  • Aseptic and biohazard processing
  • High solids feeds and gentle processing
  • Fine molecule separation and stable flux
  • Process flexibility for scale up where ultimate solids content is unknown
  • Steam-in-place (SIP) and/or hot water sanitization
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Kvick cassette holders

Kvick cassette holders

  • support our line of design-in tools for cross flow applications involving Kvick cassettes
  • are versatile devices that house Kvick cassettes and facilitates their use cross flow systems
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