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WAVE Bioreactor Literature

Manuals | Protocols

Adenovirus | Baculovirus | Cell Therapy | Disposable Technology | Mammalian Cell Culture | Microbial | Microcarriers | Monoclonal Antibodies | Protein Production | Transient Transfection | Vaccines

Download current WAVE Bioreactor Manuals, Cell Culture Protocols, technical papers and other literature about the WAVE Bioreactor. Please contact us to receive copies of papers not available on-line. If you know of any publications using a WAVE system, that are not on this list, please let us know: WAVE.Info@ge.com


WAVE Bioreactor Manuals

Publication Title   Description   Click to Download
WAVE Bioreactor Technical Reference   Technical reference describes oxygen transfer and mixing capabilities along with example applications.   Technical_Reference.pdf
WAVE Bioreactor SYSTEM2/10EH operator's manual   Operator's Manual for 2/10EH for benchtop or incubator use.   SYSTEM210EH_Manual.pdf
WAVE Bioreactor SYSTEM20/50EHT operator's manual  Operator's Manual for electric unit. For benchtop use. Includes temperature control.  SYSTEM2050EHT_US_Rev_F.pdf
WAVE Bioreactor SYSTEM200EH operator's manual  Operator's Manual for 200 liter floor-standing unit.  SYSTEM200EHCE_Manual.pdf
WAVE Bioreactor SYSTEM500/1000EH operator's manual  Operator's Manual for 500 liter floor-standing unit.  SYSTEM5001000EHCE_Manual.pdf
WAVE Bioreactor Instrumentation Manual  Operator's Manual for WAVE Bioreactor instrumentation.  Instrument_Manual.pdf
WAVEPOD operator's manual  Operator's Manual for WAVEPOD.  Instrument_Manual.pdf
PCDAQ data acquisition  Operator's Manual for PC-based control and data logging software.  PCDAQ_Ver3.33_Manual.pdf
WB Supervisor Operator's Manual  Manual for WAVE Bioreactor supervisory control and data acquisition PC system.  SCADA_Ver3.33_Manual.pdf
DOOPT20 operator's manual  Operator's Manual for DOOPT20 dissolved oxygen amplifier.  DOOPT20_Manual.pdf
PUMP20 operator's manual  Operator's Manual for PUMP20 peristaltic feed/harvest pump.  PUMP20_Manual.pdf


WAVE Bioreactor Protocols

Publication Title  Description  Click to Download
WAVE Bioreactor Systems - Cell culture procedures  
  • Cultivation of cells on Hillex microcarriers using WAVE Bioreactor Systems 2/10 and 20/50
  • Cultivation of cells on Cultispher microcarriers using WAVE Bioreactor Systems 2/10 and 20/50
  • Cultivation of cells on Cytodex 3 microcarriers using WAVE Bioreactor Systems 2/10 and 20/50
  • Cultivation of cells on Fibra-Cel carriers using WAVE Bioreactor Systems 2/10 and 20/50
  • Cellbag disposable bioreactor pretreatment for the use of chemically defined lipid supplements
  • Perfusion cell culture using WAVE Bioreactor Systems 2/10 and 20/50
  • Cultivation of CHO and HEK293 cells in PEI transfection reagent using WAVE Bioreactor Systems 2/10 and 20/50
  • Cultivation of CHO cells in suspension using WAVE Bioreactor Systems 2/10 and 20/50
  • Cultivation of CHO cells in suspension using WAVE Bioreactor System 200
  • Cultivation of HEK 293 cells in suspension using WAVE Bioreactor Systems 2/10 and 20/50
  • Cultivation of HEK 293 cells in suspension using WAVE Bioreactor System 200
  • Cultivation of hybridoma cells in suspension using WAVE Bioreactor Systems 2/10 and 20/50
  • Cultivation of hybridoma cells in suspension using WAVE Bioreactor System 200
  • Cultivation of NS0 cells in suspension using WAVE Bioreactor Systems 2/10 and 20/50
  • Cultivation of NS0 cells in suspension using WAVE Bioreactor System 200
  • Cultivation of T cells in suspension using WAVE Bioreactor Systems 2/10 and 20/50
  • Cultivation of E. coli bacteria using WAVE Bioreactor Systems 2/10 and 20/50
  • Cultivation of E. coli bacteria using WAVE Bioreactor System 200
  • Cultivation of BTI-TN-5B1-4 insect cells in suspension using WAVE Bioreactor Systems 2/10 and 20/50
  • Cultivation of BTI-TN-5B1-4 insect cells in suspension using WAVE Bioreactor System 200
  • Cultivation of Sf9 and Sf21 insect cells in suspension using WAVE Bioreactor Systems 2/10 and 20/50
  • Cultivation of Sf9 and Sf21 insect cells in suspension using WAVE Bioreactor System 200
  • Cultivation of plant cells in suspension using WAVE Bioreactor Systems 2/10 and 20/50
  • Cultivation of yeast cells using WAVE Bioreactor Systems 2/10 and 20/50
  • Cultivation of yeast cells using WAVE Bioreactor System 200
 28930894AA.pdf


Adenovirus Publications and Technical Reports

Publication Title  Date Published  Category
Production of recombinant adeno-associated vectors using two bioreactor configurations at different scales
J Virological Methods, Vol 145(2); 155-161
 2007  Adenovirus
Adenovirus Production and Recovery using a WAVE Bioreactor
SAIC- Frederick, NCI
 2004  Adenovirus
Production of Adenoviral Vectors for Gene Therapy in Suspension Serum Free Cultures
Presentation at Viral Vectors
 2003  Adenovirus

Baculovirus Publications and Technical Reports

Publication Title  Date Published  Category
Production of selenomethionyl-derivatized proteins in baculovirus-infected insect cells
Protein Science, Vol 16:2023-2029
 2007  Baculovirus
Growing cholesterol-dependent NS0 myeloma cell line in the WAVE Bioreactor system: Overcoming cholesterol-polymer interaction by using pretreated polymer or inert fluorinated ethylene propylene.
Presented at 2004 ACS. Printed Biotechnol Prog. 2005 Jul-Aug; 21 (4): 1341-6
 2005  Baculovirus
Purification of Recombinant HIS-Tagged Viral proteins and evaluation of their sensitivity and specificity for detecting viral antibodies in Rodent Sera by ELISA - Feb 01
K. Dhawan Baculovirus Conference, 2001.
 2001  Baculovirus

Cell Therapy Publications and Technical Reports

Publication Title  Date Published  Category
Considerations & Applied Solutions for Cell Therapy Product Development and Commercialization
Progenitor Cell Therapy LLC; presented at symposium
 2007  Cell Therapy
Personalized Cell-Based Medicine: Activated and Expanded T Cells for Adoptive Immunotherapy
BioProcessing Journal, Vol 6, No. 2
 2007  Cell Therapy
Lentiviral Vector Assists Gene Therapy
GEN ENG NEWS, June 1, 2007
 2007  Cell Therapy
Evolution of a Gene Therapy Company
Introgen Therapeutics - presented at EU Antibodies & Recombinant - Barcelona, Spain
 2006  Cell Therapy
GMP Production and Testing of Xcellerated T Cells for the Treatment of Patients with CLL
Cytotherapy, Vol 6, No 6, pgs 554-562
 2004  Cell Therapy
Comparison of a Static Process and a Bioreactor-based Process for the GMP Manufacture of Autologous Xcellerated T Cells for Clinical Trials
Bioprocessing Journal, Vol 2, No 6 2003
 2003  Cell Therapy

Disposable Technology Publications and Technical Reports

Publication Title  Date Published  Category
Tech Focus: Prognosticating the Future of the Bioreactor. Specific Demands Will Impact the Ongoing Evolution of this Device
Genetic Engineering News, Jan 15 2008; Vol. 28, No. 2
 2008  Disposable Technology
Whatever happened to ·.Smallpox?
Discover Magazine
 2007  Disposable Technology
Single-Use Technologies - A contract biomanufacturer's perspective
BioPharm International, Suppl, Nov 2007
 2007  Disposable Technology
WAVE Disposable Bioreactors - a pioneering technology
BioPharm International, vol 20, no. 10
 2007  Disposable Technology
CMOs Focused on Meeting Needs and Time Lines
Genetic Engineering News, Oct 1, 2007; vol 27, no. 17
 2007  Disposable Technology
Disposables crucial in future of patient-specific meds
Pharma Technologist.com
 2007  Disposable Technology
Demand Strong for Upstream Systems
GEN ENG NEWS Vol 27, No 14
 2007  Disposable Technology
"They Said it Wouldn't Work"
India Today International
 2006  Disposable Technology
Case Study of a Clinical-Scale CGMP Production Facility
BioProcess International, Vol 4, No. 6 2006
 2006  Disposable Technology
Bioprocessing Systems Go Disposable
Chemical Engineering Progress, May 2006, Vol 102, No. 5
 2006  Disposable Technology
Steel vs Bag: Comparison of Process Performance and Production Quality
Amgen
 2005  Disposable Technology
Disposable Bioreactors Become Standard Fare
GEN ENG NEWS Vol 25, No 14
 2005  Disposable Technology
Development of a Large-Scale Cell Bank in Cryobags for the Production of Biologics
Merck Research - presented at CCE IX
 2004  Disposable Technology
Validation of Bioreactors: Disposable vs. Reusable
BioProcess International Industry Yearbook
 2004  Disposable Technology

Mammalian Cell Culture Publications and Technical Reports

Publication Title  Date Published  Category
Establishment of a WAVE Bioreactor scale-down model for process development and characterization studies
Bristol-Myers Squibb. ACS 2007 presentation
 2007  Mammalian Cell Culture
Serum-Free Suspension Large-Scale Transient Transfection of CHO Cells in WAVE Bioreactors
Molecular Biotechnology, Vol 34, Issue 2, pgs 191-200
 2006  Mammalian Cell Culture
Evaluation of Disposable Bioreactors: Rapid Production of Recombinant Proteins By Several Animal Cell Lines - Oct 05
Bioprocess International Industry Yearbook, Vol 3, No. 9, October, 2005, pages 36-44.
 2005  Mammalian Cell Culture
Characterisation and Operation of a Disposable Bioreactor as a Replacement for Conventional Steam In Place Inoculum Bioreactors for Mammalian Cell Culture Processes
Lonza Biologics - presented at ACS
 2002  Mammalian Cell Culture

Microbial Publications and Technical Reports

Publication Title  Date Published  Category
Evaluation of a novel WAVE Bioreactor(R) cellbag for aerobic yeast cultivation.
Bioprocess Biosyst Eng. 2007 Mar 6
 2007  Microbial

Microcarriers Publications and Technical Reports

Publication Title  Date Published  Category
Making Waves in Cell Therapy: The WAVE Bioreactor for the Generation of Adherent and Non-adherent Cells for Clinical Use
Univ of Pennsylvania Abramson Cancer Inst.
 2007  Microcarriers
Assessing a disposable bioreactor for attachment-dependent cell cultures
Biopharm
 2006  Microcarriers

Monoclonal Antibodies Publications and Technical Reports

Publication Title  Date Published  Category
Upstream processes in antibody production: Evaluation of critical parameters
Biotechnol Adv Vol 1, 46-72
 2008  Monoclonal Antibodies
Perfusion Culture of Hybridoma Cells for Hyperproduction of IgG(2a) Monoclonal Antibody in a WAVE Bioreactor-Perfusion Culture System
Biotechnology Prog, 23(1):255-264
 2007  Monoclonal Antibodies
Cholesterol Delivery to NS0 Cells: challenges and solutions in disposable linear low-density polyethylene-based bioreactors
J Bioscience & Bioengineering, Vol 103, No. 1, pgs 50-59
 2007  Monoclonal Antibodies
Using the Allergic Immune System to Target Breast Cancer: Production of Anti-MUC1 IgE Monoclonal Antibodies
Presented at San Antonio Breast Cancer Symposium (December 14-17, 2006)
 2006  Monoclonal Antibodies
The Use of Disposable Technologies in Antibody Manufacturing Processes
Genentech
 2005  Monoclonal Antibodies
On-line Purification of Monoclonal Antibodies Using an Integrated Stirred-Tank Reactor/Expanded-Bed Adsorption System
Biotechnol. Progress, Vol 18
 2002  Monoclonal Antibodies
Evaluation of DO and pH as key parameters for cell metabolic shift in the WAVE reactor
MIT - presented at ACS
 2002  Monoclonal Antibodies
Perfusion Culture in Disposable Bioreactors
Genetic Engineering News, Vol 21, No. 7
 2001  Monoclonal Antibodies
Disposable Bioreactor for Cell Culture Using Wave-Induced Agitation
Cytotechnology, Vol 30, pgs 149-158
 1999  Monoclonal Antibodies

Protein Production Publications and Technical Reports

Publication Title  Date Published  Category
Scalability of a Disposable Bioreactor from 25L - 500L Run in Perfusion Mode with a CHO-based Cell Line
Bioprocessing Journal, Vol 3, No 4
 2004  Protein Production
Semi-automated process for the factory-like production of recombinant proteins in the baculovirus system.
Novartis - presented at Recombinant Protein Production meeting
 2004  Protein Production
Optimisation of Protein Expression and Establishment of the WAVE Bioreactor for Baculovirus/Insect cell Culture
Cytotechnology, Vol 38, pgs 77-85
 2002  Protein Production
From Puddles to Waves: Journey to Consistency of Large Scale Expression
Chiron
 2002  Protein Production

Transient Transfection Publications and Technical Reports

Publication Title  Date Published  Category
The Happy Marriage of PEI and WAVE in Large-scale transient transfection
Novartis Institute
 2004  Transient Transfection

Vaccines Publications and Technical Reports

Publication Title  Date Published  Category
Establishment of a mink enteritis vaccine production process in stirred-tank reactor and WAVE Bioreactor microcarrier culture in 1-10 L scale
Vaccine, Vol 25, Issue 20
 2007  Vaccines
WAVE microcarrier cultivation of MDCK cells for influenza virus production in serum containing and serum-free media
Vaccine, Vol 24, Issues 35-36
 2006  Vaccines
Process Considerations for Cell-Based Influenza Vaccines
Pharmaceutical Technology
 2006  Vaccines


WAVE Mixer Literature

Download manuals, brochures, technical papers and other literature about the WAVE Mixer. Please contact us to receive copies of papers not available on-line. If you know of any publications using a WAVE system, that are not on this list, please let us know: WAVE.Info@ge.com

WAVE Mixer Manuals and Brochures

Publication Title  Description  Click to Download
Wave Mixer Catalog  Guide to selecting a Wave MIXER20/50 for your application and component catalog.  WaveMixer_catalog.pdf
Wave MIXER20/50EH Manual  Installation and operating manual.  MIXER2050EH_manual.pdf
Wave MIXER20/50P Manual  Installation and operating manual.  MIXER2050P_manual.pdf
Wave MIXER500/1000EH Manual  Installation and operating manual.  WAVEMIXER5001000EH_Manual.pdf

WAVE Mixer Publications and Technical Reports

Publication Title  Date Published
Bioprocessing Tutorial: Mixing in Large Disposable Containers - Feb '04
V. Singh, Genetic Engineering News, Feb 1, 2004.
 2004
Bioprocessing Tutorial: Non-invasive Mixing in Bags - Feb '00
V. Singh, Genetic Engineering News, Feb 1, 2000.
 2000


Sterile Tube Fuser Literature

Download technical papers and other literature about the Sterile Tube Fuser. Please contact us to receive copies of papers not available on-line. If you know of any publications using a WAVE system, that are not on this list, please let us know: WAVE.Info@ge.com

Sterile Tube Fuser Publications and Technical Reports

Publication Title  Description  Date Posted  Click to Download
Sterile Tube Fuser/ Hot Lips Tube Sealer Catalog  Catalog of Sterile Tube Fuser and Sealer options and accessories  Aug 08  WaveBrochure_Aug2008.pdf
Operation and Validation Guide  Function, design and validation basis of STF-IRc     Available through purchase of STF-IR CALKIT
Equipment Validation Protoco  Validation of STF-IRc     Available through purchase of STF-IR CALKIT


Hot Lips Tube Sealer Literature

Download technical papers and other literature about the Hot Lips Tube Sealer. Please contact us to receive copies of papers not available on-line. If you know of any publications using a WAVE system, that are not on this list, please let us know: WAVE.Info@ge.com

Hot Lips Tube Sealer Publications and Technical Reports

Publication Title  Description  Date Posted  Click to Download
Sterile Tube Fuser/ Hot Lips Tube Sealer Catalog  Catalog of Sterile Tube Fuser and Sealer options and accessories  Aug 08  WaveBrochure_Aug2008.pdf
Operation and Validation Guide  Describes the function, design, and validation basis of the Hot Lips Tube Sealer     Available through purchase of HLTS-CALKIT
Validation Protocol  Validation Protocol for Hot Lips Tube Sealer     Available through purchase of HLTS-CALKIT




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