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IN Cell Analyzer 6000 is a highly sensitive, laser-based confocal imaging platform for the most demanding high-content assays and screens. Featuring a novel and proprietary optical system that incorporates an iris-like variable aperture design and next-generation sCMOS technology, IN Cell Analyzer 6000 enables you to optimize for speed and image quality for challenging and variable assays.
Most confocal HCA systems provide a non-adjustable aperture that is typically optimized for high power objectives. However, mid and low power objectives are often more enabling for high content analysis. The adjustable confocality of IN Cell Analyzer 6000 allows you to vary the confocal aperture width to match each specific imaging condition, enabling an optimal level of confocality no matter which objective or excitation wavelength you require.
Use adjustable confocal mode for wash-free assays, 3-D cell imaging, and elimination of unwanted fluorescent backgrounds – without significant loss of signal.
Additional user-friendly system features:
• Preview scanning.
• Manual microscopy mode.
• Whole-well imaging.
• Temperature and environmental control.
• Liquid handling.
• Transmitted light imaging and slide handling.
Balance speed and image quality with adjustable confocality.
IN Cell Analyzer 6000 is designed as a sensitive fluorescence imaging system, able to detect weak fluorescence signals that would typically be lost in the noise.
• Powerful lasers for fluorescence excitation
• Low noise scientific grade CMOS camera
• Low light losses in the line confocal optics
Highly uniform laser line illumination and optimized imaging optics also eliminate the need to apply flat field correction for most imaging applications.
The latest high content analysis software offers powerful analytics with a simple and intuitive interface. Developed in collaboration with GE Digital and built on Predix, GE’s platform for the industrial internet, the IN Cell image analysis software enables high-content analysis of images acquired on IN Cell Analyzer systems.
The use of 3D cell culture has been rapidly expanding in many areas of scientific research. While 3D cell culture has some significant advantages over more traditional methods like animal models and 2D cultures, it is not without its own unique challenges. Nano3D Biosciences, together with MD Anderson, have developed a magnetic 3D bioprinting technique to successfully overcome many of the difficulties associated with studying 3D biology. Learn more in this on-demand webinar: Magnetic 3D bioprinting of cells - Overcoming imaging obstacles in spheroids.
Explore our Cell Image Gallery to see the inspiring images that can be captured on the IN Cell Analyzer!
|Automation||Compatible with commercially available laboratory automation systems|
sCMOS 5.5 Mp camera (2560 × 2160 pixels)
Field-of-view at 10×: 2.78 mm2
Pixel size: 6.5 μm
|Computer||Windows 7 workstation|
Four laser blocking filters
Up to eight emission filters
Contrast-based software autofocus
Laser confocal hardware autofocus
Z stage resolution: 25 nm
|Image Acquisition Features||
Preview scan capability
Whole-well imaging capability
Manual microscope mode
|Imaging Modes||Line confocal (confocal aperture adjustable from 1 to 3 AU) Open aperture (widefield) Transmitted light (brightfield, DIC, and phase contrast imaging)|
Four lasers (405, 488, 561, and 642 nm)
LED for transmitted light imaging
|Magnification||automated; 4 positions|
|Objectives||Supplied with 10×/0.45 and 20×/0.45 Other objectives available: 2×/0.1, 4×/0.20, 40×/0.60, and 60×/0.95|
|Optical System||Proprietary epi-fluorescence based line scanning confocal system. Allows image acquisition in confocal, open aperture, and transmitted light modes.|
Transmitted light imaging
|Plate Compatability||Compatible with 6-, 12-, 24-, 48-, 96-, 384-, and 1536-well microplates|
|Plate Positioning [XY Stage]||500 nm resolution|
|Slide Compatibility||1 × 3 in. standard microscope slide|
IN Cell Investigator v2.0 onwards
IN Cell Miner HCM
|Temp. Max. [For Kinetic Assays]||42 °C|
|Temp. Min. [For Kinetic Assays]||Ambient +5 °C|
Assessing cardiac activity with high-content analysis: quantitating dynamic calcium flux and contractility with Cytiva™ Plus Cardiomyocytes and IN Cell Analyzer
Describes the use of high-content analysis to study intracellular calcium dynamics and contractility of Cytiva Plus Cardiomyocytes. IN Cell Analyzer was used to study drug effects on the intracellular calcium dynamics and contractility of Cytiva Plus Cardiomyocytes. Bright field imaging was also explored as a label-free alternative to fluorescent calcium indicators for the measurement of cell morphology and beat rate. Close
Evaluation of neurospheres with the IN Cell Analyzer 6000
The IN Cell Analyzer 6000 is a unique laser-based confocal high content imaging system with a novel and rapidly adjustable aperture inspired by the iris mechanism of the eye. Imaging thick tissues, such as neurospheres, requires confocal technology to optically section the tissue. High quality images enable robust quantitative analysis and localization of proteins in complex 3D cellular systems. Close
Live-cell population studies and live multiwell cell tracking experiments with IN Cell Analyzer 6000 high-content analysis system
We study the performance of IN Cell Analyzer 6000 in a range of cell viability and cell cycle assays and demonstrate the advantages of this laser based line-scanning confocal imager over a conventional wide-field high-content imaging system. The data show that variable confocal imaging in each fluorescence channel allows you to optimize for speed and resolution in challenging high-content multiplex assays. A precise automated stage coupled with use of an environmental chamber also makes IN Cell Analyzer 6000 suitable for long-term kinetic imaging of cell populations by enabling multi- or single-well cell tracking experiments to be performed over extended incubation periods. Close
Monitoring of lipid droplets to identify novel drugs using IN Cell Analyzer
This application note demonstrates the utility of IN Cell Analyzer 6000 and 2000-series high-content analysis imaging systems for screening to detect autophagy modulators using a fluorescence-based LD assay. Close
Cell Analysis Redefined
Learn about the benefits of IN Cell Analyzer 6000 as a highly sensitive, laser-based confocal imaging platform with adjustable aperture for the most demanding high-content assays and screens. Close
IN Cell Analyzer High-Content Cellular Analysis System
Overview of the IN Cell Analyzer High-Content Analysis (HCA) system. Provides featured highlights and configurations of the IN Cell Analyzer 2000 and 6000 instruments and describes IN Cell Investigator image analysis and data visualization software, IN Cell Miner HCM data management platform, and IN Cell Analyzer Compliance Manager software. Close
IN Cell Analyzer acquisition software update v4.5
Describes significant new enhancements incorporated into v4.5 of the IN Cell Analyzer acquisition software. Close
IN Cell Image Analysis Software
Improved usability and analytics for better results. Close
High-throughput spheroid imaging and formation for using magnetic 3D bioprinting
Magnetic 3D bioprinting works by magnetizing cells with NanoShuttle (NS), then printing them with magnetic forces in CELLSTAR flat-bottom cell-repellent plates. Close
Cancer Research: GE Healthcare Cell Analysis portfolio in action
Cancer Researchers around the world unite in their studies to bring about improved patient outcomes with more effective and better tolerated treatments. At GE Healthcare, we are proud that our Cell Analysis portfolio plays a meaningful role generating high quality cellular images to advance cancer research – with over 300 publications in 2015 alone. Close
Drug discovery: GE Healthcare cell analysis portfolio in action
In drug discovery, it is estimated that it takes $1–2.6 bn and around 12-15 y to bring a new drug to market. This arduous pathway is often described as a funnel where the wide end of the funnel is target identification at the beginning of drug discovery and the narrow end of the funnel is clinical development. The funnel narrows as more and more compounds fail to pass tests for efficacy and toxicity, among others. Strikingly, only 1 in 5000 drug candidates that enter preclinical testing will be approved by the FDA. Here, a recent selection of drug discovery publications from the IN Cell Analyzer, DeltaVision™ Elite, DeltaVision OMX, and Cytell™ Cell Imaging Systems were analyzed for placement within the pathway. A small selection of publications were chosen for more extensive characterization. As expected given the shape of the funnel, the top of the funnel was very heavily represented with 34% of the total publications in target identification and only 2% in preclinical development. Close
Selected IN Cell Analyzer publications
Publications utilizing the IN Cell Analyzer 2000, IN Cell Analyzer 2200, and IN Cell Analyzer 6000 have increased eight fold in the past five years. Here, a selection of 79 papers from the last two years is featured and categorized according to application. Close
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|40× 0.6 NA CFI S Plan Fluor ELWD (ASAC)||29051871||No price available.|
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|40× 0.95 NA CFI Plan Apo Lambda (ASAC)||29051876||No price available.|
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|60× 0.95 NA CFI Plan Apo Lambda (ASAC)||29051877||No price available.|
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|Cytiva Cell Health Assay for High Content Analysis||29-0244-68||No price available.|
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