Biotherapeutic Discovery and Development
GE Healthcare provides a comprehensive portfolio of solutions and products to meet the needs of the whole biotherapeutic workflow, from target identification, through all aspects of discovery and development, to manufacturing and post-market surveillance. Central to these solutions are our integrated expertise in bioprocessing, a wide range of chromatography and filtration solutions and sophisticated systems for protein analysis.
From simple beginnings using animal-derived proteins, technological advances have opened up many approaches to producing biotherapeutics (also referred to as biologics). Recombinant proteins or antibodies are increasingly being developed to augment or replace small organic compounds. Perhaps the first and best known application of a biotherapeutic was the treatment of diabetes using pancreatic porcine insulin. Though a purity of 99% was reached by the mid-1970s mainly due to separation technologies such as HPLC, allergic reactions remained a problem. Today, biosynthetic "human" insulin derived using recombinant DNA technology has almost completely replaced insulin derived from animal sources. The biotherapeutics armory now includes a vast range of therapeutics thanks to the latest advances in antibody technology and stem cells. The bioproduction process is pivotal to product quality and is subject to close regulatory monitoring, with the production of various biotherapeutics each having their own special requirements.
As we understand more about how biological systems work at a molecular level, we expand the possibilities of intervening in disease processes through engineered biotherapeutics in the form of proteins, nucleic acids, or even whole live cells.
The biomanufacturing process, as well as the safety and efficacy of the final product, is subject to rigorous regulatory scrutiny.
Identify molecules involved at key stages of the disease process – and use that knowledge as a basis for the discovery of novel biotherapeutics
Modern technologies and analytical tools are needed to help cell-based therapies realize their full potential to revolutionize human medicine