Upstream Bioprocessing and Filtration
Related Technologies
Related Brands
The challenge for upstream MAb platform operations is the production of standardized, highly productive cell lines. WAVE Bioreactor Systems, using disposable bioreactors, provide a convenient and scalable approach to cell culture.
In addition, GE Healthcare’s single-use technologies include aseptic connectors, preconditioned filters, and bags and tubing assemblies. These disposable solutions make bioprocessing simpler, faster, and minimize contamination risks.
WAVE Bioreactor Systems have been used extensively for monoclonal antibody production. Cells and culture medium only come into contact with a presterile, disposable bioreactor chamber called a Cellbag where oxygen and nutrient transfer is maintained by the rocking motion induced by the system. As Cellbag bioreactors are disposable, they require no cleaning or sterilization, which simplifies operation and protects against cross-contamination.
ReadyToProcess disposable filtration devices, bags, tubing, and connectors work seamlessly together to make upstream and downstream processes easier and more efficient. After processing, the entire circuit can be disposed, eliminating the time and cost associated with cleaning and cleaning validation.
ReadyToProcess filters are preconditioned, sterile cartridges and capsules for cross flow (CFF/TFF) and normal flow filtration operations (NFF). The NFF devices provide efficient, sterilizing grade filtration for a wide range of biopharmaceutical solutions and CFF devices are available in a wide variety of ultrafiltration molecular weight cut-offs and pore sizes.
ReadyCircuit bag and tubing assemblies, used together with filter assemblies, form self-contained purification modules that maintain an aseptic flow path. We offer a broad range of products enable the design of almost any fluid processing circuit imaginable.
ReadyMate Disposable Aseptic Connectors allow secure connections, for example to filtration systems. Sensor assemblies terminating with ReadyMate connectors are also available to reliably monitor pressure, temperature, and conductivity.
We also offer automated filtration systems, as well as traditional NFF and CFF filters.
Use the online ReadyToProcess Configurator tool to configure and price a ReadyCircuit single-use fluid management assembly. Create a custom single-use assembly or an assembly using off the shelf plug and play products including cross flow filters (CFF/TFF filters), normal flow filters, sensors, tubing, and bags.


