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Developing biomanufacturing processes is a complex task of balancing the quality (purity) of the product with process robustness and a minimum of unit operations to improve economy.
At the earliest stage of development, laboratory-scale purification is required to obtain material for discovery and development. Even at this stage, future process development must be considered to avoid the use of methods that cannot be efficiently scaled up and use of materials that are too expensive or hazardous to use in manufacturing processes. Requirements also change when moving a purification process from an explorative environment to a highly regulated production environment.
UNICORN 6 Control Software for ÄKTA avant has an integrated Design of Experiments (DoE) tool that speeds up process development.
PreDictor plates and PreDictor RoboColumn™ miniaturized columns support HTPD by allowing parallel screening of chromatography conditions for binding, wash, and elution.
HiScreen columns, prepacked with a range of BioProcess chromatography media (resins), are designed for method optimization and parameter screening.
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