RNA interference (RNAi) is an endogenous post-transcriptional gene regulatory mechanism mediated by non-coding RNA molecules known as microRNAs. microRNAs can target hundreds of genes simultaneously and induce subtle but reproducible shifts in gene expression.
This mechanism can be used for targeted gene silencing by introduction of nucleic acid based tools that are specially designed to work within the endogenous RNAi pathway. These molecules are taken up by the RNA induced silencing complex (RISC) to target specific mRNAs for degradation or to either supplement or inhibit endogenous microRNAs.
Currently, there are three primary categories of RNAi tools to perform these functions: small interfering RNA (siRNA), short hairpin RNA (shRNA), and microRNA mimics and inhibitors.
Pre-designed genome-wide reagents for siGENOME, ON-TARGETplus, and Accell product lines. Choose highly potent siRNAs for human, mouse, and rat.
SMARTchoice, GIPZ, TRIPZ, and TRC lentiviral shRNA products designed for optimal gene silencing. Choose from viral vectors, viral particles, or viral pools.
microRNA modulation tools including miRIDIAN microRNA Mimics, microRNA Hairpin Inhibitors, and shMIMIC Lentiviral microRNAs.
Design, order, and learn more about custom siRNA, single-stranded RNA, and microRNA products. Use our free, online siRNA design tool or specify your own sequences.
Everything you need for high-quality, reproducible results. Choose from negative and positive controls as well as transfection indicators for all product lines.
Accelerate discovery using one of the widest selections of RNAi screening collections available. Choose from whole genome, gene families, or custom libraries.
Complete your experiment with all necessary ancillary reagents, including buffers, water, and specialized cell culture media.
