We’ve all been there…finding everyday bioprocessing a bit more challenging than we imagined when we woke up that morning. For Gene and Eva, in the cartoon series Trials of a medicine maker, this is certainly a reality.

Viral vectors: restless and demanding?

Bioprocessing cartoon on viral vectors for gene therapy and biopharma

Manufacturing viral vectors, like many unchartered areas, can seem stressful compared to other biologics. But Gene finds out that there are easy ways to meet the challenges and live in peace with even the most demanding vector.

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Can digital switch off the biopharma manufacturing lights?

Bioprocessing cartoon on automation and digital solutions for the biopharma industry

Hey! Who turned the light out?! Gene and Eva may be wandering in the dark…but not aimlessly. Their achievement of lights out manufacturing in biopharma may seem futuristic, but by integrating digital we can get closer to this reality than we think.

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Talent crunch in bioprocessing, lock up your staff…

Medicine maker cartoon on the talent crunch in the biopharma industry

The bioprocessing talent pool seems to be draining faster than it’s filling up. As always, Gene thinks he has everything under control. But there are better ways to keep skilled staff than keeping them locked up, such as hands-on training in bioprocess techniques.

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Tired of watching cells grow? Try process intensification

Tired of watching cells grow? Try process intensification

Gene would much rather be riding the fast train and surfing the waves, but sadly he’s stuck on the slow train. Inoculum train expansion can be exhausting. Help is on its way though, in the shape of process intensification.

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Cell therapy: new beginnings, old challenges?

Trials of a medicine maker cartoon Cell therapy: new beginnings, old challenges?

There’s a new Gene in cell and gene therapy…and he is not too thrilled about it. He should be though! Join our medicine makers as they dive into the exciting world of stem cells, CAR T-cells, regenerative medicine, and more.

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Raw material, risk, and rough interrogations

Trials of a medicine maker cartoon Quality in Raw Materials

Aha! No wonder Gene and Eva got variability in their results. Mice living in the cell culture ingredients just don’t make for great bioprocessing results. An open communication between Gene and Eva and their supplier could sure improve their raw material and risk management. Perhaps they should go digital?

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DoE or DOA…don’t leave your outcome to chance

Trials of a medicine maker cartoon cell culture DOE

A little more help from Gene would go a long way. Eva seems to know the basics of design of experiments (DoE). But Gene’s project management skills are certainly in question, especially as it’s Eva who is taking the heat.

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Don’t get bitten by the bioburden bug

Trials of a medicine maker cartoon bioburden

Bioburden is the stuff nightmares are made of. No wonder Eva can’t sleep. The last thing she wants is a bioburden control issue in her bioprocessing facility. Just as any biomanufacturer, her priority is to make every product safe and effective for patients.

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Tech transfer: smooth sailing?

Trials of a medicine maker cartoon tech transfer

It must have been one hungry dog Gene’s got. Hopefully Gene managed to pull together the hard copies in the end. There’s plenty to consider in tech transfer. But there are also great resources available, like training courses for bioprocess scale-up and tech transfer.

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Chromatography: column packing for dummies?

Trials of a medicine maker cartoon column packing

Captain Column sure looks a bit discouraged…No wonder when his first mission was completed by a shiny new automatic chromatography column! But Eva was right to send Gene on a column packing training course. Manual packing is a time-consuming art.

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Overcoming the bioprocess buffer bottleneck

Bioprocessing cartoon on buffer management in large-scale bioprocessing

Eva wishes she was on vacation, but she knows her team would struggle with buffer management without her. As biomanufacturing titers go up, so do downstream buffer volumes, but there are clever solutions available for buffer management.

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Continuous bioprocessing: smart or scary?

Continuous bioprocessing: smart or scary?

Great that Gene and Eva didn’t give up on trying to get the benefits of continuous biomanufacturing across. Because there are many. Take greater flexibility for example, or smaller facilities with less utilities, less staff, and less cost.

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Security of supply: make a supplier’s weakness your strength

Security of supply: make a supplier’s weakness your strength

Oh yes, Gene should just trust Eva on this one. No one wants to gamble on the safety, efficiency, or availability of a biopharmaceutical. A tip is to keep an eye out for suppliers with a structured, risk-based approach to security of supply.

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Prefabricated facilities: cut time and capital risk

Trials of a medicine maker cartoon modular manufacturing facilities

What would you add to your biomanufacturing facility if you had the chance? Gene’s sauna might be out of the question. But going for a modular prefabricated facility can add more benefits than you might imagine.

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Collaborative PD outsourcing: why closer is better

Outsourcing biopharmaceutical process development

Sharing process details externally might seem too close for comfort. But when it comes to process development outsourcing, a close collaboration can actually bring added benefits.

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The next best thing to predicting the future

Trials of a Medicine Maker Cartoon Single-use

Wouldn’t it be great to be able to see into the future? That way you could decide your biomanufacturing strategy early on. As we continue to dream about this unlikely scenario, let’s join Gene and Eva as they look at the next best thing— single-use technologies.

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The secret to PAT's (kitchen) success

Process analytical technologies in biomanufacturing

Comparing kitchens to cleanrooms might seem strange. But, as medicine makers Gene and Eva discovered, process analytical technologies (PAT) can bring success in both places. Here’s why.

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