CAR T cells: closed and semi-automated processing
A robust workflow that can be adapted for cGMP compliance in commercial production. Achieves 1 × 1010 expanded T cells in 8 days.
Lentiviral vector upstream process
Upstream lentiviral vector process with stable producer cell line that can be adapted for commercial manufacturing. Scales linearly from 5 to 28 L in Xcellerex bioreactors yielding ≥ 1010 TU/L of LV-GFP.
Controlled endpoint in cryopreservation
This study was designed to answer the question: When is it safe to transfer cell samples from a controlled-rate freezer to liquid nitrogen storage?
Is a rapid cooling step needed?
This study shows comparable results when freezing cells with or without a rapid-cooling nucleation step.
Water free vs water bath cell thawing
Read about this benchmarking study and benefits of dry thawing technology.
Developments in cell expansion for cell processing
Expand your knowledge on perfusion, our rocking technology and more by reading through our latest papers and posters.
CBMG and GE Healthcare collaboration
CBMG accelerates cell therapy manufacturing with GE Healthcare’s start-to-finish FlexFactory for cellular therapies.
Interrupted cooling in cryopreservation
How does a power interruption during cooling affect post-thaw cell viability? This study demonstrates minimal effect of power outages and interrupted cooling during cryopreservation when using a VIA Freeze controlled-rate freezer.
Delivering LN2-free multi-bag cryopreservation
A proof-of-concept study that demonstrates the controlled cooling of large volume biological samples with high and consistent post-thaw recovery. An alternative solution to cryopreserving with liquid nitrogen.
Enabling LN2-free large-volume cryopreservation in vials
Cooling protocol and proof-of-concept study for the cryopreservation of large-volume biological samples in cryovials. Achieve high and consistent post-thaw recovery of up to 50 mL in this liquid nitrogen-free cell freezing method.
Case study: lentiviral vector process development
Development of a scalable process to produce high-yield lentiviral vector batches using stable, suspension-based production methods.
Unifying cell therapy logistics and manufacturing
For cell and gene therapies, the supply chain and logistics are critical. Collaboration is the key to solving data management and process variability challenges.