Large-scale bioprocess buffer management
Reclaim time and space by downsizing volumes
Overcoming the buffer bottleneck
As titers go up, so do downstream buffer volumes. Preparing and handling large liquid volumes can strain your time, budget, and space.
Manual buffer management processes are struggling to keep up – but there is another way.
Shrink buffer volumes down to size
Overcome large process liquid volumes, saving both time and space with:
- inline dilution – reduces buffer volumes by using buffer concentrates
- inline conditioning (IC) – takes dilution one step further, prepares multiple buffers from the same stocks and ensures precise inline control of pH and conductivity
- HyClone buffers and stock solutions –ready-to-use buffers, in single-use connectable bags
Integrate chromatography and inline buffer preparation
Compared with preparing buffers separately, integrating buffer preparation with the chromatography step saves time and reduces facility footprint. Here, buffers are loaded onto the column just in time and sequentially. For further streamlining, connect ready-made HyClone stock solutions to an IC system.
Will my buffers work?
Our IC system should work for any type of chromatography, even those requiring specialized buffers, such as IMAC. Buffers can be formulated regardless of buffer system, salt, or additives.READ OUR FAQS
Process liquids ready when you are
Another way to overcome the buffer bottleneck is by outsourcing buffer production. Ready-to-use HyClone buffers and process liquids are sterile preparations delivered in single-use bags up to 1000 L. The ready-to-use bags can be connected directly to the unit operation, eliminating cleaning and validation requirements.